publication . Doctoral thesis . 2016

Immunogenetic determinants of susceptibility/resistance to Mycobacterium ulcerans infection: a population based study – Benin biological bank on Buruli ulcer

Capela, Carlos Alberto Pereira;
Open Access English
  • Published: 22 Nov 2016
  • Country: Portugal
Abstract
Tese de Doutoramento - Doutoramento em Medicina Buruli ulcer (BU) is an infectious disease found in tropical regions of Africa, America, Asia, and Australia. Most of the cases are reported in West Africa and BU is considered a neglected tropical disease by the World Health Organization (WHO). This necrotising skin infection is caused by Mycobacterium ulcerans that secretes the exotoxin mycolactone as its main virulence factor. There is emerging evidence for a major role of genetic factors contributing to either BU development or disease progression. Indeed, not all individuals, even after sustained exposure to M. ulcerans in endemic wetlands, develop BU and when...
Subjects
free text keywords: :Medicina Clínica [Ciências Médicas]
Related Organizations
Funded by
FCT| PEst-C/SAU/LA0026/2013
Project
PEst-C/SAU/LA0026/2013
Strategic Project - LA 26 - 2013-2014
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 133016
  • Funding stream: COMPETE
,
EC| BURULIVAC
Project
BURULIVAC
Identification and development of vaccine candidates for Buruli Ulcer Disease
  • Funder: European Commission (EC)
  • Project Code: 241500
  • Funding stream: FP7 | SP1 | HEALTH
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