publication . Article . Book . Part of book or chapter of book . 2016

AMPK in Pathogens

Mesquita, I.; Moreira, D.; Sampaio-Marques, B.; Laforge, M.; Cordeiro-Da-Silva, A.; Ludovico, P.; Estaquier, J.; Ricardo Silvestre;
  • Published: 01 Jan 2016
Abstract
During host-pathogen interactions, a complex web of events is crucial for the outcome of infection. Pathogen recognition triggers powerful cellular signaling events that is translated into the induction and maintenance of innate and adaptive host immunity against infection. In opposition, pathogens employ active mechanisms to manipulate host cell regulatory pathways toward their proliferation and survival. Among these, subversion of host cell energy metabolism by pathogens is currently recognized to play an important role in microbial growth and persistence. Extensive studies have documented the role of AMP-activated protein kinase (AMPK) signaling, a central ce...
Subjects
free text keywords: SNF1/AMPK, Host-pathogen interactions, Infection, Metabolism, Microbial auxotrophy, Bioenergetics, Science & Technology, AMP-Activated Protein Kinases/antagonists & inhibitors, AMP-Activated Protein Kinases/genetics, AMP-Activated Protein Kinases/immunology, Anti-Infective Agents/therapeutic use, Autophagy/drug effects, Autophagy/immunology, Bacteria/drug effects, Bacteria/genetics, Bacteria/metabolism, Bacterial Infections/drug therapy, Bacterial Infections/enzymology, Bacterial Infections/genetics, Bacterial Infections/virology, Fungi/drug effects, Fungi/enzymology, Fungi/genetics, Gene Expression Regulation, Host-Pathogen Interactions/drug effects, Host-Pathogen Interactions/genetics, Humans, Immunity, Innate/drug effects, Molecular Targeted Therapy, Mycoses/drug therapy, Mycoses/enzymology, Mycoses/genetics, Mycoses/virology, Protein Subunits/antagonists & inhibitors, Protein Subunits/genetics, Protein Subunits/immunology, Protein-Serine-Threonine Kinases/antagonists & inhibitors, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/immunology, Signal Transduction, Virus Diseases/drug therapy, Virus Diseases/enzymology, Virus Diseases/genetics, Virus Diseases/virology, Viruses/drug effects, Viruses/genetics, Viruses/metabolism, Energy homeostasis, Pathogen, Protein kinase A, Cell signaling, AMPK, Immunity, Eukaryote, biology.organism_classification, biology, Cell biology
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
FCT| SFRH/BD/91543/2012
Project
SFRH/BD/91543/2012
ROLE OF SIRTUINS IN THE CONTEXT OF HOST-PATHOGEN INTERACTION
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: SFRH/BD/91543/2012
  • Funding stream: SFRH | Doutoramento

Abu Kwaik Y, Bumann D (2013) Microbial quest for food in vivo: 'nutritional virulence' as an emerging paradigm. Cell Microbiol 15(6):882-890. doi:10.1111/cmi.12138.

Acosta-Serrano A, Vassella E, Liniger M, Kunz Renggli C, Brun R, Roditi I, Englund PT (2001) The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly. Proc Natl Acad Sci U S A 98(4):1513-1518. [OpenAIRE]

doi:10.1073/pnas.041611698.

Adam RD (2000) The Giardia lamblia genome. Int J Parasitol 30(4):475-484.

Abstract
During host-pathogen interactions, a complex web of events is crucial for the outcome of infection. Pathogen recognition triggers powerful cellular signaling events that is translated into the induction and maintenance of innate and adaptive host immunity against infection. In opposition, pathogens employ active mechanisms to manipulate host cell regulatory pathways toward their proliferation and survival. Among these, subversion of host cell energy metabolism by pathogens is currently recognized to play an important role in microbial growth and persistence. Extensive studies have documented the role of AMP-activated protein kinase (AMPK) signaling, a central ce...
Subjects
free text keywords: SNF1/AMPK, Host-pathogen interactions, Infection, Metabolism, Microbial auxotrophy, Bioenergetics, Science & Technology, AMP-Activated Protein Kinases/antagonists & inhibitors, AMP-Activated Protein Kinases/genetics, AMP-Activated Protein Kinases/immunology, Anti-Infective Agents/therapeutic use, Autophagy/drug effects, Autophagy/immunology, Bacteria/drug effects, Bacteria/genetics, Bacteria/metabolism, Bacterial Infections/drug therapy, Bacterial Infections/enzymology, Bacterial Infections/genetics, Bacterial Infections/virology, Fungi/drug effects, Fungi/enzymology, Fungi/genetics, Gene Expression Regulation, Host-Pathogen Interactions/drug effects, Host-Pathogen Interactions/genetics, Humans, Immunity, Innate/drug effects, Molecular Targeted Therapy, Mycoses/drug therapy, Mycoses/enzymology, Mycoses/genetics, Mycoses/virology, Protein Subunits/antagonists & inhibitors, Protein Subunits/genetics, Protein Subunits/immunology, Protein-Serine-Threonine Kinases/antagonists & inhibitors, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/immunology, Signal Transduction, Virus Diseases/drug therapy, Virus Diseases/enzymology, Virus Diseases/genetics, Virus Diseases/virology, Viruses/drug effects, Viruses/genetics, Viruses/metabolism, Energy homeostasis, Pathogen, Protein kinase A, Cell signaling, AMPK, Immunity, Eukaryote, biology.organism_classification, biology, Cell biology
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
FCT| SFRH/BD/91543/2012
Project
SFRH/BD/91543/2012
ROLE OF SIRTUINS IN THE CONTEXT OF HOST-PATHOGEN INTERACTION
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: SFRH/BD/91543/2012
  • Funding stream: SFRH | Doutoramento

Abu Kwaik Y, Bumann D (2013) Microbial quest for food in vivo: 'nutritional virulence' as an emerging paradigm. Cell Microbiol 15(6):882-890. doi:10.1111/cmi.12138.

Acosta-Serrano A, Vassella E, Liniger M, Kunz Renggli C, Brun R, Roditi I, Englund PT (2001) The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly. Proc Natl Acad Sci U S A 98(4):1513-1518. [OpenAIRE]

doi:10.1073/pnas.041611698.

Adam RD (2000) The Giardia lamblia genome. Int J Parasitol 30(4):475-484.

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