publication . Doctoral thesis . 2014

Predictions of RNA-binding ability and aggregation propensity of proteins

Agostini, Federico, 1985-;
Open Access English
  • Published: 16 Jun 2014
  • Publisher: Universitat Pompeu Fabra
Abstract
RNA-binding proteins (RBPs) control the fate of a multitude of coding and non-coding transcripts. Formation of ribonucleoprotein (RNP) complexes fine-tunes regulation of post-transcriptional events and influences gene expression. Recently, it has been observed that non-canonical proteins with RNA-binding ability are enriched in structurally disordered and low-complexity regions that are generally involved in functional and dysfunctional associations. Therefore, it is possible that interactions with RNA protect unstructured protein domains from aberrant associations or aggregation. Nevertheless, the mechanisms that prevent protein aggregation and the role of RNA ...
Subjects
free text keywords: Intrinsically disordered region (IDR), Long non-coding RNA (lncRNA), Low-complexity sequence (LCS), Protein aggregate, Ribonucleoprotein complex (RNP complex), RNA granule, RNA recognition element (RRE), RNA-binding protein (RBP), Stress granules, Región intrínsecamente desordenada, ARN largo no codificante, Secuencia de baja complejidad, Agregado proteico, Complejo de ribonucleoproteína, Gránulo de ARN, Elemento de reconocimiento de ARN, Proteína de unión al ARN, Gránulos de estrés, 577
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