publication . Doctoral thesis . 2014

Investigating a role for p63 in prostate stem cells, cancer and metastasis

Di Giacomo, Valeria, 1983-;
Open Access English
  • Published: 12 Dec 2014
  • Publisher: Universitat Pompeu Fabra
Abstract
P63 is a transcription factor of the p53 family with key roles in embryonic development, stem cells and cancer. P63-deficient mice fail to form stratified and glandular epithelia, including the prostate, demonstrating a critical function for this protein in prostate development. The P63 gene encodes two different isoform groups, TA and N, which can act as tumor suppressors or oncogenes respectively in different tumors. In the prostate gland, Np63 is the main isoform expressed specifically in basal stem cells. There is evidence that p63+ basal stem cells are the cells-of-origin in prostate cancer. However the mature tumor has a luminal phenotype and loss of p6...
Subjects
free text keywords: ΔNp63α, p53, Càncer de pròstata, Prostate cancer, Ratolins deficients per a p63, p63-Deficient mice, Cèl•lules mare de la pròstata, Prostate stem cells, Metastatic colonization to the bone, Colonització metàstica de l’os, Transcription factors, Factors de transcripció, p63, 616.6
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