publication . Doctoral thesis . 2010

Cellular mRNA decay factors involved in the hepatitis C virus life cycle

Mina Ibarra, Leonardo Bruno;
Open Access English
  • Published: 21 May 2010
  • Publisher: Universitat Pompeu Fabra
Abstract
The group of positive strand RNA ((+)RNA) viruses includes numerous plant, animal and human pathogens such as the hepatitis C virus (HCV). Their viral genomes mimic cellular mRNAs, however, besides acting as messengers for translation of viral proteins, they also act as templates for viral replication. Since these two functions are mutually exclusive, a key step in the replication of all (+) RNA viruses is the regulated exit of the genomic RNAs from the cellular translation machinery to the viral replication complexes. By using a model system that allows the replication of the plant (+) RNA Brome Mosaic Virus in yeast, it was shown by our group that the cellular...
Subjects
Medical Subject Headings: viruses
free text keywords: Vía de degradación de RNA, Virus RNA, Replicación, Traducción, Cáncer, Factores celulares, Virus de la Hepatitis C, HCV, RNA decay pathway, Replication, RNA virus, Translation, Host factors, Cancer, Hepatitis C Virus, 57
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