publication . Doctoral thesis . 2013

Common neuroplasticity mechanisms underlying drugs and food reward

Guegan, Thomas, 1983-;
Open Access English
  • Published: 05 Nov 2013
  • Publisher: Universitat Pompeu Fabra
Abstract
Drug addiction and some eating disorders present striking similarities in their behavioural symptoms. It has been postulated that excessive consumption of drugs of abuse and palatable food could lead to the development of similar neuronal alterations in the brainreward circuit that may account for the resemblance of these pathologies. In the present thesis, we demonstrate that repeated operant training with palatable food promotes behavioural alterations and structural plasticity changes in the esocorticolimbic circuit that are reminiscent to those observed with drugs of abuse. Furthermore, we identify the cannabinoid receptor 1 as a common neurobiological subst...
Subjects
Medical Subject Headings: digestive, oral, and skin physiology
free text keywords: Drug addiction, Eating disorders, Structural plasticity, Cannabinoid receptor 1, Morphine locomotor sensitization, Palatable food, Conditioned place preference, Drug and palatable food craving, Adicción, Trastornos alimentarios, Plasticidad estructural, Receptor cannabinoide 1, Sensibilización locomotora a la morfina, Comida palatable, Preferencia de plaza condicionada, Ansia de consumir drogas y comida palatable, 616.89
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