publication . Doctoral thesis . 2016

The nanoparticle corona in the deep lung : pulmonary surfactant adsorption and its role in nano-bio interactions

Räsch, Simon Sebastian;
Open Access English
  • Published: 01 Jan 2016
  • Country: Germany
Abstract
Nanoparticles (NPs) for drug delivery to the respiratory tract are of considerable interest, for the treatment of chronic and acute pulmonary and systemic disorders, promising the potential for sustained release and targeted delivery. Although the targets for these formulations are usually cells, the NPs, once inhaled, first encounter a non-cellular barrier in the deep lung: the pulmonary surfactant (PS). This is a lipid-protein mixture which covers the alveoli and enables gas exchange as a result of its surface tension lowering function. While the interaction of NPs with plasma proteins is routinely elucidated, the adsorption of lung lipids and proteins onto NP...
Subjects
free text keywords: Nanopartikel, Lunge, Proteomanalyse, Pulmonaler Surfactant, Nano-Bio Interaktionen, pulmonary surfactant, nanoparticle surface, biological barrier, bio-nano interface, lipid-protein interaction, ddc:500, ddc:620
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