publication . Doctoral thesis . 1982

Studies in the use of liposomes in the development of an animal model of Gaucher's disease

Weereratne, Elaine Annmarie Hishani;
Open Access English
  • Published: 01 Jan 1982
  • Country: United Kingdom
Gaucher's disease is characterised by a malfunction of the enzyme glucocerebrosidase which hydrolyses the glycolipid glucocerebroside. Mammalian tissues contain at least two beta-glucosidases capable of releasing glucose from the synthetic substrate 4-methylumbelliferyl-beta-D-glucopyranoside (4-MUGlc). One of these enzymes, a membrane bound 'acid' form, also hydrolyses glucocerebroside and is deficient in patients with Gaucher's disease. The synthetic substrate is used to measure this latter enzyme in the routine diagnosis of Gaucher's disease. Diverse conditions have been used by different workers to assay this enzyme in various animal and tissue sources. An a...
free text keywords: Biochemistry, Department of Biochemistry
Related Organizations
Download from
Any information missing or wrong?Report an Issue