Characterization of Active Site Structure in CYP121: A CYTOCHROME P450 ESSENTIAL FOR VIABILITY OF MYCOBACTERIUM TUBERCULOSIS H37Rv*S⃞

Other literature type English OPEN
McLean, Kirsty J.; Carroll, Paul; Lewis, D. Geraint; Dunford, Adrian J.; Seward, Harriet E.; Neeli, Rajasekhar; Cheesman, Myles R.; Marsollier, Laurent; Douglas, Philip; Smith, W. Ewen; Rosenkrands, Ida; Cole, Stewart T.; Leys, David; Parish, Tanya; Munro, Andrew W.;
(2008)

Mycobacterium tuberculosis (Mtb) cytochrome P450 gene CYP121 is shown to be essential for viability of the bacterium in vitro by gene knock-out with complementation. Production of CYP121 protein in Mtb cells is demonstrated. Minimum inhibitory concentration ... View more
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