Characterization of Active Site Structure in CYP121: A CYTOCHROME P450 ESSENTIAL FOR VIABILITY OF MYCOBACTERIUM TUBERCULOSIS H37Rv*S⃞

Other literature type English OPEN
McLean, Kirsty J. ; Carroll, Paul ; Lewis, D. Geraint ; Dunford, Adrian J. ; Seward, Harriet E. ; Neeli, Rajasekhar ; Cheesman, Myles R. ; Marsollier, Laurent ; Douglas, Philip ; Smith, W. Ewen ; Rosenkrands, Ida ; Cole, Stewart T. ; Leys, David ; Parish, Tanya ; Munro, Andrew W. (2008)

Mycobacterium tuberculosis (Mtb) cytochrome P450 gene CYP121 is shown to be essential for viability of the bacterium in vitro by gene knock-out with complementation. Production of CYP121 protein in Mtb cells is demonstrated. Minimum inhibitory concentration ... View more
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