publication . Article . 2015

Elements Involved In Promoting Eosinophilic Gastrointestinal Disorders.

Anil Mishra;
Open Access English
  • Published: 01 Aug 2015 Journal: Journal of genetic syndromes & gene therapy, volume 6, issue 2 (eissn: 2157-7412, Copyright policy)
Eosinophilic gastrointestinal disorders (EGID) are food allergen-induced allergic gastrointestinal disorders, characterized by accumulation of highly induced eosinophils in different segments of gastrointestinal tract along with eosinophil microabssess and extracellular eosinophilic granules in the epithelial layer. EGID are both IgE- and cell-mediated group of diseases that include eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE) and eosinophilic colitis (EC). Despite the increased incidences and considerable progress made in understanding EGID pathogenesis. The mechanism is still not well understood. It has been s...
free text keywords: Article, Eosinophils, EoE, EGE, EGID, Food allergy, Interleukin, iNKT cells, Immunoglobulin E, biology.protein, biology, Eosinophilic gastroenteritis, medicine.disease, medicine, Clinical endpoint, Eosinophilic esophagitis, Eosinophilic, Gastroenterology, medicine.medical_specialty, Eosinophil, medicine.anatomical_structure, Eosinophilia, medicine.symptom, Immunology, Disease, Internal medicine, business.industry, business
Related Organizations
Funded by
NIH| Mechanistic Analysis of Eosinophilic Esophagitis.
  • Funder: National Institutes of Health (NIH)
  • Project Code: 7R01DK067255-08
NIH| Immune signaling molecules involved in promoting the pathogenesis of eosinophilic esophagitis (EoE)
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2R01AI080581-09A1
125 references, page 1 of 9

Boyce, JA, Friend, D, Matsumoto, R, Austen, KF, Owen, WF. Differentiation in vitro of hybrid eosinophil/basophil granulocytes: Autocrine function of an eosinophil developmental intermediate. Journal of Experimental Medicine. 1995; 182: 49-57 [OpenAIRE] [PubMed]

Rothenberg, ME. Eosinophilia. N Engl J Med. 1998; 338: 1592-1600 [OpenAIRE] [PubMed]

Zaidi, AK, Mussarat, A, Mishra, A. Diagnostic and therapeutic strategies for eosinophilic esophagitis. Clin Pract (Lond). 2014; 11: 351-367 [OpenAIRE] [PubMed]

Mishra, A, Hogan, SP, Brandt, EB, Wagner, N, Crossman, MW. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. The Journal of biological chemistry. 2002; 277: 4406-4412 [OpenAIRE] [PubMed]

Mishra, A, Hogan, SP, Lee, JJ, Foster, PS, Rothenberg, ME. Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J Clin Invest. 1999; 103: 1719-1727 [OpenAIRE] [PubMed]

Pascal, RR, Gramlich, TL, Parker, KM, Gansler, TS. Geographic variations in eosinophil concentration in normal colonic mucosa. Mod Pathol. 1997; 10: 363-365 [PubMed]

Polydorides, AD, Banner, BF, Hannaway, PJ, Yantiss, RK. Evaluation of site-specific and seasonal variation in colonic mucosal eosinophils. Hum Pathol. 2008; 39: 832-836 [OpenAIRE] [PubMed]

Powell, N, Walker, MM, Talley, NJ. Gastrointestinal eosinophils in health, disease and functional disorders. Nature reviews. Gastroenterology and hepatology. 2010; 7: 146-156 [PubMed]

Rothenberg, ME, Hogan, SP. The eosinophil. Annu Rev Immunol. 2006; 24: 147-174 [PubMed]

Rosenberg, null, Lee, F. Eosinophils in health and diseases. 2014

Mishra, A, Hogan, SP, Brandt, EB, Rothenberg, ME. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest. 2001; 107: 83-90 [OpenAIRE] [PubMed]

Hogan, SP, Mishra, A, Brandt, EB, Royalty, MP, Pope, SM. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol. 2001; 2: 353-360 [OpenAIRE] [PubMed]

Dutt, P, Shukla, JS, Ventateshaiah, SU, Mariswamy, SJ, Mattner, J. Allergen-induced interleukin-18 promotes experimental eosinophilic oesophagitis in mice. Immunol Cell Biol. 2015

Mishra, A, Hogan, SP, Brandt, EB, Rothenberg, ME. IL-5 promotes eosinophil trafficking to the esophagus. J Immunol. 2002; 168: 2464-2469 [OpenAIRE] [PubMed]

Hogan, SP, Mishra, A, Brandt, EB, Foster, PS, Rothenberg, ME. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy. Proceedings of the National Academy of Sciences of the United States of America. 2000; 97: 6681-6686 [OpenAIRE] [PubMed]

125 references, page 1 of 9
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