publication . Article . Other literature type . 2010

Differential Modulation of Sonic-Hedgehog-Induced Cerebellar Granule Cell Precursor Proliferation by the IGF Signaling Network

Fernandez, Carla; Tatard, Valérie M.; Bertrand, Nicolas; Dahmane, Nadia;
Open Access
  • Published: 01 Mar 2010 Journal: Developmental Neuroscience, volume 32, pages 59-70 (issn: 0378-5866, eissn: 1421-9859, Copyright policy)
  • Publisher: S. Karger AG
Abstract
The molecular mechanisms regulating organ growth and size remain unclear. Sonic hedgehog (SHH) signaling is a major player in the regulation of cerebellar development: SHH is secreted by Purkinje neurons and acts on the proliferation of granule cell precursors (GCPs) in the external germinal layer. These then become postmitotic and form the internal granular layer but do so in the presence of SHH ligand, begging the question of how the proliferative response to SHH signaling is downregulated in differentiating GCPs. Here, we have determined the precise cellular localization of the expression of insulin-like growth factor (IGF) network components in the developin...
Subjects
Medical Subject Headings: animal structuresembryonic structures
free text keywords: Developmental Neuroscience, Neurology, Cellular localization, Anatomy, Cerebellar granule cell precursor proliferation, Cell biology, Endocrinology, medicine.medical_specialty, medicine, Cellular differentiation, Sonic hedgehog, biology.protein, biology, Granule cell, medicine.anatomical_structure, Cell growth, Growth factor, medicine.medical_treatment, Internal medicine, Signal transduction, Original Paper
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publication . Article . Other literature type . 2010

Differential Modulation of Sonic-Hedgehog-Induced Cerebellar Granule Cell Precursor Proliferation by the IGF Signaling Network

Fernandez, Carla; Tatard, Valérie M.; Bertrand, Nicolas; Dahmane, Nadia;