Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry

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Saradhi, U. V. R. Vijaya; Gupta, Sneha V.; Chiu, Ming; Wang, Jiang; Ling, Yonghua; Liu, Zhongfa; Newman, David J.; Covey, Joseph M.; Kinghorn, A. Douglas; Marcucci, Guido; Lucas, David M.; Grever, Michael R.; Phelps, Mitch A.; Chan, Kenneth K.;

A sensitive and specific liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of the plant natural product silvestrol in mice, using ansamitocin P-3 as the internal standard. The method was validated in plasma with a l... View more
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