publication . Other literature type . Article . 2018

DNA methylation of a PLPP3 MIR transposon-based enhancer promotes an osteogenic programme in calcific aortic valve disease

Mkannez, Ghada; Gagné-Ouellet, Valérie; Jalloul Nsaibia, Mohamed; Boulanger, Marie-Chloé; Rosa, Mickael; Argaud, Deborah; Hadji, Fayez; Gaudreault, Nathalie; Rhéaume, Gabrielle; Bouchard, Luigi; ...
  • Published: 02 May 2018
  • Publisher: Oxford University Press (OUP)
Abstract
AIMS: Calcific aortic valve disease (CAVD) is characterized by the osteogenic transition of valve interstitial cells (VICs). In CAVD, lysophosphatidic acid (LysoPA), a lipid mediator with potent osteogenic activity, is produced in the aortic valve (AV) and is degraded by membrane-associated phospholipid phosphatases (PLPPs). We thus hypothesized that a dysregulation of PLPPs could participate to the osteogenic reprograming of VICs during CAVD. METHODS AND RESULTS: The expression of PLPPs was examined in human control and mineralized AVs and comprehensive analyses were performed to document the gene regulation and impact of PLPPs on the osteogenic transition of V...
Subjects
free text keywords: Physiology (medical), Physiology, Cardiology and Cardiovascular Medicine, Gene, Molecular biology, Biology, DNA methylation, Aortic valve calcification, Intron, Transposable element, Cardiology, medicine.medical_specialty, medicine, Calcification, medicine.disease, Enhancer, Internal medicine, Phosphoric monoester hydrolases, Original Articles
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