publication . Other literature type . 2012

Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall

Bayer, Arnold S.; Schneider, Tanja; Sahl, Hans-Georg;
Open Access English
  • Published: 05 Dec 2012
Abstract
The bactericidal, cell membrane-targeting lipopeptide antibiotic daptomycin (DAP) is an important agent in treating invasive Staphylococcus aureus infections. However, there have been numerous recent reports of development of daptomycin-resistance (DAP-R) during therapy with this agent. The mechanisms of DAP-R in S. aureus appear to be quite diverse. DAP-R strains often exhibit progressive accumulation of single nucleotide polymorphisms in the multipeptide resistance factor gene (mprF) and the yycFG components of the yycFGHI operon. Both loci are involved in key cell membrane (CM) events, with mprF being responsible for the synthesis and outer CM translocation o...
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Other literature type . 2012
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