publication . Other literature type . Article . 2012

Effect of Wolbachia on replication of West Nile virus in a mosquito cell line and adult mosquitoes.

Hussain, Mazhar; Lu, Guangjin; Torres, Shessy; Edmonds, Judith H.; Kay, Brian H.; Khromykh, Alexander A.; Asgari, Sassan;
  • Published: 31 Oct 2012
  • Publisher: American Society for Microbiology
Abstract
Wolbachia as an endosymbiont is widespread in insects and other arthropods and is best known for reproductive manipulations of the host. Recently, it has been shown that wMelpop and wMel strains of Wolbachia inhibit the replication of several RNA viruses, including dengue virus, and other vector-borne pathogens (e.g., Plasmodium and filarial nematodes) in mosquitoes, providing an alternative approach to limit the transmission of vector-borne pathogens. In this study, we tested the effect of Wolbachia on the replication of West Nile Virus (WNV). Surprisingly, accumulation of the genomic RNA of WNV for all three strains of WNV tested (New York 99, Kunjin, and New ...
Subjects
Medical Subject Headings: parasitic diseasesbiochemical phenomena, metabolism, and nutritionbacteriareproductive and urinary physiologyviruses
free text keywords: Immunology, Insect Science, Microbiology, Virology, Dengue fever, medicine.disease, medicine, Aedes, biology.organism_classification, biology, Dengue virus, medicine.disease_cause, Virus, Aedes aegypti, RNA virus, Viral replication, Wolbachia, Virus-Cell Interactions
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