publication . Article . Other literature type . 2017

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

Ulrich Beuers; Benno Zehnder; Mark J. Kwakkenbos; Adriaan P. IJzerman; Gerard J. P. van Westen; Joanne M. Donkers; Stan F.J. van de Graaf; Stephan Urban; Stephan Urban; Ronald P.J. Oude Elferink;
Open Access English
  • Published: 10 Nov 2017
  • Country: Netherlands
<p>The sodium taurocholate co-transporting polypeptide (NTCP, SLC10A1) is the main hepatic transporter of conjugated bile acids, and the entry receptor for hepatitis B virus (HBV) and hepatitis delta virus (HDV). Myrcludex B, a synthetic peptide mimicking the NTCP-binding domain of HBV, effectively blocks HBV and HDV infection. In addition, Myrcludex B inhibits NTCP-mediated bile acid uptake, suggesting that also other NTCP inhibitors could potentially be a novel treatment of HBV/HDV infection. This study aims to identify clinically-applied compounds intervening with NTCP-mediated bile acid transport and HBV/HDV infection. 1280 FDA/EMA-approved drugs were screen...
Persistent Identifiers
Medical Subject Headings: digestive systemvirus diseases
free text keywords: Article, Multidisciplinary, Virus, Taurocholic acid, chemistry.chemical_compound, chemistry, Virology, Viral entry, SLC10A1, biology.protein, biology, Hepatitis B, medicine.disease, medicine, Bile acid, medicine.drug_class, Hepatitis B virus, medicine.disease_cause, Organic anion transporter 1, business.industry, business, lcsh:Medicine, lcsh:R, lcsh:Science, lcsh:Q
Funded by
Improving Metabolism via Prolonged Bile Acid Signalling targeting hepatic bile acid uptake to fight metabolic diseases
  • Funder: European Commission (EC)
  • Project Code: 337479
  • Funding stream: FP7 | SP2 | ERC
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Article . 2017
Provider: NARCIS
Scientific Reports
Article . 2017
Provider: Crossref
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