publication . Article . Other literature type . 2018

Regulatory dendritic cell therapy: From rodents to clinical application

Raïch-Regué Dalia; Glancy Megan; Thomson Angus W.;
Open Access
  • Published: 13 Nov 2018 Journal: Immunology Letters, volume 161, pages 216-221 (issn: 0165-2478, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Dendritic cells (DC) are highly-specialized, bone marrow-derived antigen-presenting cells that induce or regulate innate and adaptive immunity. Regulatory or “tolerogenic” DC play a crucial role in maintaining self tolerance in the healthy steady-state. These regulatory innate immune cells subvert naïve or memory T cell responses by various mechanisms. Regulatory DC (DCreg) also exhibit the ability to induce or restore T cell tolerance in many animal models of autoimmune disease or transplant rejection. There is also evidence that adoptive transfer of DCreg can regulate T cell responses in non-human primates and humans. Important insights gained from in vitro st...
Subjects
free text keywords: Immunology, Immunology and Allergy, Memory T cell, medicine.anatomical_structure, medicine, Transplantation, Acquired immune system, Transplant rejection, medicine.disease, Cell therapy, T cell, Immune tolerance, Immune system, business.industry, business, Article
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