Secreted Aspartyl Proteinases and Interactions of Candida albicans with Human Endothelial Cells

Other literature type English OPEN
Ibrahim, Ashraf S. ; Filler, Scott G. ; Sanglard, Dominique ; Edwards, John E. ; Hube, Bernhard (1998)
  • Publisher: American Society for Microbiology
  • Subject: Fungal and Parasitic Infections

The endothelial cell interactions of homozygous null mutants of Candida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicans adherence to endothelial cells.
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