Secreted Aspartyl Proteinases and Interactions of Candida albicans with Human Endothelial Cells
Other literature type
Ibrahim, Ashraf S.
Filler, Scott G.
Edwards, John E.
- Publisher: American Society for Microbiology
Fungal and Parasitic Infections
The endothelial cell interactions of homozygous null mutants of Candida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicans adherence to endothelial cells.