publication . Article . Other literature type . 2017

Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro.

Zheng, Bei; Wang, Jiadan; Tang, Leilei; Tan, Chao; Zhao, Zhe; Xiao, Yi; Ge, Renshan; Zhu, Danyan;
Open Access English
  • Published: 01 Jan 2017 Journal: International Journal of Biological Sciences, volume 13, issue 1, pages 110-121 (eissn: 1449-2288, Copyright policy)
  • Publisher: Ivyspring International Publisher
Abstract
Rictor is a key regulatory/structural subunit of the mammalian target of rapamycin complex 2 (mTORC2) and is required for phosphorylation of Akt at serine 473. It plays an important role in cell survival, actin cytoskeleton organization and other processes in embryogenesis. However, the role of Rictor/mTORC2 in the embryonic cardiac differentiation has been uncovered. In the present study, we examined a possible link between Rictor expression and cardiomyocyte differentiation of the mouse embryonic stem (mES) cells. Knockdown of Rictor by shRNA significantly reduced the phosphorylation of Akt at serine 473 followed by a decrease in cardiomyocyte differentiation ...
Subjects
Medical Subject Headings: digestive, oral, and skin physiology
free text keywords: Research Paper, Rictor/mTORC2, embryonic stem cell, cardiomyocyte differentiation, cell-cell junction, electrophysiology., Biology, Molecular biology, Cellular differentiation, Protein kinase B, Gene knockdown, Induced pluripotent stem cell, mTORC2, Actin cytoskeleton organization, Cell biology, Embryoid body
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publication . Article . Other literature type . 2017

Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro.

Zheng, Bei; Wang, Jiadan; Tang, Leilei; Tan, Chao; Zhao, Zhe; Xiao, Yi; Ge, Renshan; Zhu, Danyan;