publication . Other literature type . Article . 2010

Whole transcriptome analysis of the fasting and fed Burmese python heart: insights into extreme physiological cardiac adaptation

Christopher E. Wall; Steven Cozza; Cecilia A. Riquelme; W. Richard McCombie; Joseph K. Heimiller; Thomas G. Marr; Leslie A. Leinwand;
Open Access English
  • Published: 02 Nov 2010
  • Publisher: American Physiological Society
Abstract
<jats:p> The infrequently feeding Burmese python ( Python molurus ) experiences significant and rapid postprandial cardiac hypertrophy followed by regression as digestion is completed. To begin to explore the molecular mechanisms of this response, we have sequenced and assembled the fasted and postfed Burmese python heart transcriptomes with Illumina technology using the chicken ( Gallus gallus ) genome as a reference. In addition, we have used RNA-seq analysis to identify differences in the expression of biological processes and signaling pathways between fasted, 1 day postfed (DPF), and 3 DPF hearts. Out of a combined transcriptome of ∼2,800 mRNAs, 464 genes w...
Subjects
Medical Subject Headings: animal structures
free text keywords: Call for Papers: Technology Development for Physiological Systems, Genetics, Physiology, Gene, Biology, Gene expression, Regulation of gene expression, Burmese python, biology.organism_classification, Genome, Transcriptome, RNA-Seq, Gene expression profiling
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publication . Other literature type . Article . 2010

Whole transcriptome analysis of the fasting and fed Burmese python heart: insights into extreme physiological cardiac adaptation

Christopher E. Wall; Steven Cozza; Cecilia A. Riquelme; W. Richard McCombie; Joseph K. Heimiller; Thomas G. Marr; Leslie A. Leinwand;