Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

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Wang, Cheng; Tan, Zhijia; Niu, Ben; Tsang, Kwok Yeung; Tai, Andrew; Chan, Wilson C W; Lo, Rebecca L K; Leung, Keith K H; Dung, Nelson W F; Itoh, Nobuyuki; Zhang, Michael Q; Chan, Danny; Cheah, Kathryn Song Eng;

The integrated stress response (ISR) is activated by diverse forms of cellular stress, including endoplasmic reticulum (ER) stress, and is associated with diseases. However, the molecular mechanism(s) whereby the ISR impacts on differentiation is incompletely understood... View more
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