publication . Article . Other literature type . 2008

Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain.

Palkovits, M.; Harvey-White, J.; Liu, J.; Kovacs, ZS.; Bobest, M.; Lovas, G.; Bagó, A.G.; Kunos, G.;
Open Access
  • Published: 05 Feb 2008 Journal: Neuroscience, volume 152, pages 1,032-1,039 (issn: 0306-4522, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Tissue levels of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) have been determined in 16 regions and nuclei from human brains, using liquid chromatography/in-line mass spectrometry. Measurements in brain samples stored at −80 °C for 2 months to 13 years indicated that endocannabinoids were stable under such conditions. In contrast, the postmortal delay had a strong effect on brain endocannabinoid levels, as documented in brain samples microdissected and frozen 1–6 h postmortem, and in neurosurgical samples 0, 5, 30, 60, 180 and 360 min after their removal from the brain. The tissue levels of AEA increased continuously and in a region-dependent man...
Subjects
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: General Neuroscience, Endocrinology, medicine.medical_specialty, medicine, Anatomy, Cannabinoid, medicine.medical_treatment, Nucleus accumbens, Chemistry, Spinal trigeminal nucleus, medicine.anatomical_structure, Lateral hypothalamus, Internal medicine, Anandamide, chemistry.chemical_compound, Human brain, Central nervous system, Striatum, Article
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publication . Article . Other literature type . 2008

Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain.

Palkovits, M.; Harvey-White, J.; Liu, J.; Kovacs, ZS.; Bobest, M.; Lovas, G.; Bagó, A.G.; Kunos, G.;