publication . Article . 2019

SAT-463 Familial X-Linked Acrogigantism: Postnatal Outcomes and Tumor Pathology in a Prenatally Diagnosed Infant and His Affected Mother

Wise-Oringer, Brittany; Zanazzi, George; Gordon, Rebecca; Wardlaw, Sharon; William, Christopher; Kohn, Brenda; Wisoff, Jeffrey; Oberfield, Sharon;
Open Access
  • Published: 01 Apr 2019 Journal: Journal of the Endocrine Society, volume 3 (eissn: 2472-1972, Copyright policy)
  • Publisher: The Endocrine Society
Abstract
Abstract Background: X-linked acrogigantism (X-LAG), a condition of infant-onset acrogigantism marked by elevated levels of GH, IGF-1, and PRL, is extremely rare with 33 cases reported in the literature (1), including 7 total familial cases from 3 kindreds. Clinical Case: The patient’s mother, diagnosed with acrogigantism at 21 months of age, underwent pituitary tumor excision at 24 months with the expected subsequent hypopituitarism, diabetes insipidus, and seizure disorder. For over 30 years, stable GH, IGF-1, and PRL levels and serial MRI studies indicated no tumor recurrence. On pre-conception planning genetic studies, X-LAG was diagnosed: SNP microarray sho...
Subjects
free text keywords: Medicine, business.industry, business, Obstetrics, medicine.medical_specialty, Tumor Pathology, X-LINKED ACROGIGANTISM, Neuroendocrinology and Pituitary, Pituitary Tumors Case Reports
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publication . Article . 2019

SAT-463 Familial X-Linked Acrogigantism: Postnatal Outcomes and Tumor Pathology in a Prenatally Diagnosed Infant and His Affected Mother

Wise-Oringer, Brittany; Zanazzi, George; Gordon, Rebecca; Wardlaw, Sharon; William, Christopher; Kohn, Brenda; Wisoff, Jeffrey; Oberfield, Sharon;