publication . Other literature type . Article . 2005

Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity

Zavialov, Andrey V.; Engström, Åke;
  • Published: 26 Sep 2005
  • Publisher: Portland Press Ltd.
Abstract
<jats:p>Two distinct isoenzymes of ADA (adenosine deaminase), ADA1 and ADA2, have been found in humans. Inherited mutations in ADA1 result in SCID (severe combined immunodeficiency). This observation has led to extensive studies of the structure and function of this enzyme that have revealed an important role for it in lymphocyte activation. In contrast, the physiological role of ADA2 is unknown. ADA2 is found in negligible quantities in serum and may be produced by monocytes/macrophages. ADA2 activity in the serum is increased in various diseases in which monocyte/macrophage cells are activated. In the present study, we report that ADA2 is a heparin-binding pro...
Subjects
free text keywords: Cell Biology, Biochemistry, Molecular Biology, Extracellular, Enzyme, chemistry.chemical_classification, chemistry, Adenosine, medicine.drug, medicine, Adenosine deaminase, biology.protein, biology, Monocyte, medicine.anatomical_structure, AMP deaminase, Severe combined immunodeficiency, medicine.disease, Growth factor, medicine.medical_treatment, Research Article
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publication . Other literature type . Article . 2005

Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity

Zavialov, Andrey V.; Engström, Åke;