Immunosuppressive Effect of B7-H4 Pathway in a Murine Systemic Lupus Erythematosus Model

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Xiao, Ze Xiu; Zheng, Xu; Hu, Li; Wang, Julie; Olsen, Nancy; Zheng, Song Guo;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Immunology,volume 8 (eissn: 1664-3224)
  • Related identifiers: pmc: PMC5732181, doi: 10.3389/fimmu.2017.01765
  • Subject: systemic lupus erythematosus | autoimmunity | Original Research | B7-H4 | Immunology | dendritic cell | CD4+ T-cell
    mesheuropmc: skin and connective tissue diseases

B7-H4, one of the co-stimulatory molecules of the B7 family, has been shown to play an important role in negatively regulating the adaptive immune response by inhibiting the proliferation, activation, and cytokine production of T cells. In this study, we investigate the... View more
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