publication . Other literature type . Article . 2017

ROLE OF MITOCHONDRIAL PYRUVATE CARRIER 2 (MPC2) ACETYLATION

Shraddha S. Vadvalkar; Satoshi Matsuzaki; Craig A. Eyster; Jennifer R. Giorgione; Lee B. Bockus; Caroline S. Kinter; Michael Kinter; Kenneth M. Humphries;
  • Published: 01 Feb 2017
  • Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
Abstract
Abstract Alterations in mitochondrial function contribute to diabetic cardiomyopathy. We have previously shown that heart mitochondrial proteins are hyper-acetylated in OVE26 mice, a transgenic model of type 1 diabetes. However, the universality of this modification and its functional consequences are not well established. In this study, we demonstrate that Akita type 1 diabetic mice exhibit hyper-acetylation. Functionally, isolated Akita heart mitochondria have significantly impaired maximal (state 3) respiration with physiological pyruvate (0.1 mM) but not with 1.0 mM pyruvate. In contrast, pyruvate dehydrogenase activity is significantly decreased regardless ...
Subjects
free text keywords: Bioenergetics, Mitochondrial pyruvate carrier 2, Acetylation, Mitochondrion, Type 1 diabetes, medicine.disease, medicine, Mitochondrial pyruvate transport, Pyruvate transport, Diabetic cardiomyopathy, Biology, Respiration, Biochemistry
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2017

ROLE OF MITOCHONDRIAL PYRUVATE CARRIER 2 (MPC2) ACETYLATION

Shraddha S. Vadvalkar; Satoshi Matsuzaki; Craig A. Eyster; Jennifer R. Giorgione; Lee B. Bockus; Caroline S. Kinter; Michael Kinter; Kenneth M. Humphries;