publication . Article . Other literature type . 2009

TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40

Jabara, Haifa H.; Weng, Yu; Sannikova, Tatyana; Geha, Raif S.;
  • Published: 19 Feb 2009
  • Publisher: Oxford University Press (OUP)
Abstract
The isotype switch defect in CD40−/− mice is corrected by wild-type (WT) CD40 transgene, but not by a mutant CD40 transgene that does not bind tumor necrosis factor receptor-associated factors (TRAF) 2 and 3. To define the individual roles of TRAF2 and TRAF3 in CD40 activation of B cells, we introduced mutant CD40 transgenes that selectively lack the ability to bind TRAF2 (ΔTR2), TRAF3 (ΔTR3) or both (ΔTR2,3) into B cells of CD40−/− mice. Serum IgG1 and IgE levels, IgG1 antibody response to sub-optimal doses of the T cell-dependent antigen keyhole limpet hemocyanin, germinal center formation, CD40-mediated proliferation, isotype switching and activation of the n...
Subjects
Medical Subject Headings: hemic and immune systems
free text keywords: Immunology, General Medicine, Immunoglobulin class switching, Keyhole limpet hemocyanin, biology.protein, biology, Molecular biology, CD40, Immunoglobulin G, Isotype, Germinal center, Transgene, Antigen, Original Research Papers
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publication . Article . Other literature type . 2009

TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40

Jabara, Haifa H.; Weng, Yu; Sannikova, Tatyana; Geha, Raif S.;