publication . Article . Other literature type . 2006

Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor.

Kristopher K Frese; Isabel J Latorre; Sang-Hyuk Chung; Georgina Caruana; Alan Bernstein; Stephen N Jones; Lawrence A Donehower; Monica J Justice; Craig C Garner; Ronald T Javier;
Open Access
  • Published: 02 Mar 2006 Journal: The EMBO Journal, volume 25, pages 1,406-1,417 (issn: 0261-4189, eissn: 1460-2075, Copyright policy)
  • Publisher: Wiley
Abstract
The fact that several different human virus oncoproteins, including adenovirus type 9 E4-ORF1, evolved to target the Dlg1 mammalian homolog of the membrane-associated Drosophila discs-large tumor suppressor has implicated this cellular factor in human cancer. Despite a general belief that such interactions function solely to inactivate this suspected human tumor suppressor protein, we demonstrate here that E4-ORF1 specifically requires endogenous Dlg1 to provoke oncogenic activation of phosphatidylinositol 3-kinase (PI3K) in cells. Based on our results, we propose a model wherein E4-ORF1 binding to Dlg1 triggers the resulting complex to translocate to the plasma...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Immunology and Microbiology, General Neuroscience, Molecular Biology, Transfection, Tumor suppressor gene, PI3K/AKT/mTOR pathway, Suppressor, law.invention, law, Transport protein, Phosphatidylinositol, chemistry.chemical_compound, chemistry, Biology, DLG1, biology.protein, Genetics, Phosphatidylinositol 3-Kinases, Article
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publication . Article . Other literature type . 2006

Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor.

Kristopher K Frese; Isabel J Latorre; Sang-Hyuk Chung; Georgina Caruana; Alan Bernstein; Stephen N Jones; Lawrence A Donehower; Monica J Justice; Craig C Garner; Ronald T Javier;