publication . Article . 2020

Identification of Superficial White Matter Abnormalities in Alzheimer’s Disease and Mild Cognitive Impairment Using Diffusion Tensor Imaging

Bigham, Bahare; Zamanpour, Seyed Amir; Zemorshidi, Fariba; Boroumand, Farzaneh; Zare, Hoda;
Open Access English
  • Published: 01 Feb 2020 Journal: Journal of Alzheimer's Disease Reports, volume 4, issue 1, pages 49-59 (eissn: 2542-4823, Copyright policy)
  • Publisher: IOS Press
Abstract
Background: Diffusion tensor imaging (DTI) estimates the microstructural alterations of the brain, as a magnetic resonance imaging (MRI)-based neuroimaging technique. Prior DTI studies reported decreased structural integrity of the superficial white matter (SWM) in the brain diseases. Objective: This study aimed to determine the diffusion characteristics of SWM in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) using tractography and region of interest (ROI) approaches. Methods: The diffusion MRI data were downloaded from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database on 24 patients with AD, 24 with MCI, and 24 normal control (NC) s...
Subjects
Medical Subject Headings: mental disordersnervous systembehavioral disciplines and activities
free text keywords: Research Report, Alzheimer’s disease, diffusion tensor imaging, mild cognitive impairment, superficial white matter, tractography
Related Organizations
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
Communities
Neuroinformatics
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