publication . Article . 2015

Effect of experimental stress on the small bowel and colon in healthy humans.

S. E. Pritchard; K. C. Garsed; C. L. Hoad; M. Lingaya; R. Banwait; W. Thongborisute; E. Roberts; C. Costigan; L. Marciani; P. A. Gowland; ...
Open Access English
  • Published: 01 Feb 2015 Journal: Neurogastroenterology and Motility, volume 27, issue 4, pages 542-549 (issn: 1350-1925, eissn: 1365-2982, Copyright policy)
  • Publisher: Blackwell Publishing Ltd
Abstract
Background Symptoms of irritable bowel syndrome (IBS) are frequently reported to be exacerbated by stress. Animal studies suggest that corticotrophin releasing hormone (CRH) mediates the effect of stress on the bowel. We have shown that stressed IBS patients with diarrhea have constricted small bowels. We hypothesized that we could mimic this effect by applying experimental stress in the form of either hand immersion in ice water or CRH injection in healthy volunteers (HV). Methods The postprandial effect of the cold pressor test (repeated hand immersion in ice cold water) and injection of CRH, were assessed vs control in two groups of 18 HVs. Key Results CRH pr...
Subjects
Medical Subject Headings: endocrine systemhormones, hormone substitutes, and hormone antagonists
free text keywords: Original Articles, colon, MRI, small bowel water, stress, volume, Gastroenterology, Physiology, Endocrine and Autonomic Systems, Internal medicine, medicine.medical_specialty, medicine, Animal studies, Endocrinology, business.industry, business, Diabetes mellitus, medicine.disease, Diarrhea, medicine.symptom, Hormone, Irritable bowel syndrome, Magnetic resonance imaging, medicine.diagnostic_test, Corticotropin-releasing hormone, Hydrocortisone, medicine.drug
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