publication . Article . Other literature type . 2018

Hijacking Dlg1 for Oncogenic Phosphatidylinositol 3-Kinase Activation in Human Epithelial Cells Is a Conserved Mechanism of Human Adenovirus E4-ORF1 Proteins

Kumar, Manish; Kong, Kathleen; Javier, Ronald T.;
  • Published: 13 Nov 2018
Abstract
The E4-ORF1 gene of human adenoviruses encodes a 14-kDa protein that promotes viral replication as well as cellular metabolic reprogramming, survival, and transformation by constitutively activating cellular phosphatidylinositol 3-kinase (PI3K). We recently reported that the E4-ORF1 protein from subgroup D human adenovirus type 9 upregulates and oncogenically activates PI3K by a novel mechanism involving separate interactions of E4-ORF1 with cellular discs large 1 (Dlg1) and PI3K to form a ternary complex that translocates to the plasma membrane (K. Kong, M. Kumar, M. Taruishi, and R. T. Javier, PLoS Pathog. 10:e1004102, 2014, doi:10.1371/journal.ppat.1004102). ...
Subjects
Medical Subject Headings: viruses
free text keywords: Immunology, Insect Science, Microbiology, Virology, Plasma protein binding, Cell culture, Membrane protein, Kinase, Viral protein, medicine.disease_cause, medicine, Viral replication, Biology, Molecular biology, Genetic enhancement, DLG1, biology.protein, Transformation and Oncogenesis
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publication . Article . Other literature type . 2018

Hijacking Dlg1 for Oncogenic Phosphatidylinositol 3-Kinase Activation in Human Epithelial Cells Is a Conserved Mechanism of Human Adenovirus E4-ORF1 Proteins

Kumar, Manish; Kong, Kathleen; Javier, Ronald T.;