publication . Other literature type . Article . 1985

Strength of the human mixed lymphocyte reaction (MLR) and its suppression by azathioprine or 6-mercaptopurine.

SA Al-Safi; JL Maddocks;
Open Access English
  • Published: 01 Jan 1985
Abstract
Azathioprine (36 microM) had a significantly (P less than 0.00003) greater inhibitory effect on human MLR responses below 20,000 counts/min than on responses above 20,000 counts/min. In contrast, 6-mercaptopurine (100 microM) had a similar suppressive effect on MLR responses below and above 20,000 counts/min suggesting it has a different mode of action to azathioprine.
Subjects
free text keywords: Research Article, Pharmacology (medical), Pharmacology, Mode of action, Mixed lymphocyte reaction, Endocrinology, medicine.medical_specialty, medicine, Chemistry, Inhibitory effect, Azathioprine, medicine.drug, Biological activity, Internal medicine, Mechanism of action, medicine.symptom, Mercaptopurine
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