Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming

Article English OPEN
Sedegah, Martha ; Hollingdale, Michael R ; Farooq, Fouzia ; Ganeshan, Harini ; Belmonte, Maria ; Huang, Jun ; Abot, Esteban ; Limbach, Keith ; Chuang, Ilin ; Tamminga, Cindy ; Epstein, Judith E ; Villasante, Eileen (2015)
  • Publisher: Taylor & Francis
  • Journal: Human Vaccines & Immunotherapeutics, volume 11, issue 11, pages 2,705-2,715 (issn: 2164-5515, eissn: 2164-554X)
  • Related identifiers: doi: 10.1080/21645515.2015.1019186, pmc: PMC4685686
  • Subject: DNA -prime | AMA1 | CSP | vaccine | antibody | T cells | Research Papers | adenovirus-boost | malaria | efficacy | CHMI
    mesheuropmc: complex mixtures

We have previously shown that a DNA-prime followed by an adenovirus-5 boost vaccine containing CSP and AMA1 (DNA/Ad) successfully protected 4 of 15 subjects to controlled human malaria infection (CHMI). However, the adenovirus-5 vaccine alone (AdCA) failed to induce pro... View more
Share - Bookmark