Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice

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Abshagen, Kerstin; König, Matthias; Hoppe, Andreas; Müller, Isabell; Ebert, Matthias; Weng, Honglei; Holzhütter, Herrmann-Georg; Zanger, Ulrich M.; Bode, Johannes; Vollmar, Brigitte; Thomas, Maria; Dooley, Steven;
  • Publisher: Springer Nature
  • Journal: BMC Systems Biology,volume 9,issue 1 (issn: 1752-0509, eissn: 1752-0509)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4654904, doi: 10.1186/s12918-015-0229-0
  • Subject: Systems biology | Molecular Biology | Applied Mathematics | Liver injury | Research Article | Cell proliferation | 570 Life sciences | Virtual liver network | 570 | Mouse | Bile duct ligation | 610 Medical sciences Medicine | Cholestasis | Morphological profiling | 610 | Fibrosis | Modelling and Simulation | Structural Biology

Background Disrupted bile secretion leads to liver damage characterized by inflammation, fibrosis, eventually cirrhosis, and hepatocellular cancer. As obstructive cholestasis often progresses insidiously, markers for the diagnosis and staging of the disease are urgently... View more
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