publication . Article . 1995

Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients.

VM Laurence; R Ward; IF Dennis; NM Bleehen;
Open Access English
  • Published: 01 Jan 1995 Journal: British Journal of Cancer, volume 72, issue 1, pages 198-205 (issn: 0007-0920, eissn: 1532-1827, Copyright policy)
Abstract
Nicotinamide and carbogen breathing are both effective radiosensitisers in experimental tumour models and are even more effective in combination. This study was to investigate the feasibility of using the agents in combination in patients and to measure their effect on tumour oxygenation. Twelve patients with advanced malignant disease were treated with 4-6 g of oral nicotinamide (NCT) in tablet formulation. Ten of these 12 patients breathed carbogen (95% oxygen, 5% carbon dioxide) for up to 20 min at presumed peak plasma NCT concentration (Cpeak) and had tumour oxygen partial pressure (pO2) measured using the Eppendorf pO2) histograph. The mean Cpeak values wer...
Subjects
free text keywords: Research Article, Cancer Research, Oncology, Oxygenation, Toxicity, Carbogen, Pharmacokinetics, Anesthesia, Inhalation, Breathing, Carbogen Breathing, Medicine, business.industry, business, Nicotinamide, chemistry.chemical_compound, chemistry
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 1995

Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients.

VM Laurence; R Ward; IF Dennis; NM Bleehen;