Analysis of the mechanism of action of non-deletion hereditary persistence of fetal hemoglobin mutants in transgenic mice

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Li, Qiliang; Duan, Zhi-Jun; Stamatoyannopoulos, George;
(2001)

Transgenic mice carrying an Aγ gene construct containing a –382 5′ truncation of the Aγ gene promoter have a phenotype of hereditary persistence of fetal hemoglobin (HPFH) but, when the CACCC box of the –382Aγ promoter is deleted, there is no γ gene expression in the ad... View more
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