Proteasome substrate capture and gate opening by the accessory factor PafE from Mycobacterium tuberculosis

Other literature type English OPEN
Hu, Kuan; Jastrab, Jordan B.; Zhang, Susan; Kovach, Amanda; Zhao, Gongpu; Darwin, K. Heran; Li, Huilin;

In all domains of life, proteasomes are gated, chambered proteases that require opening by activators to facilitate protein degradation. Twelve proteasome accessory factor E (PafE) monomers assemble into a single dodecameric ring that promotes proteolysis required for t... View more
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