publication . Other literature type . 2013

A common variant highly associated with plasma VEGFA levels also contributes to the variation of both LDL-C and HDL-C[S]

Stathopoulou, Maria G.; Bonnefond, Amélie; Ndiaye, Ndeye Coumba; Azimi-Nezhad, Mohsen; El Shamieh, Said; Saleh, Abdelsalam; Rancier, Marc; Siest, Gerard; Lamont, John; Fitzgerald, Peter; ...
Open Access English
  • Published: 01 Feb 2013
  • Publisher: The American Society for Biochemistry and Molecular Biology
Vascular endothelial growth factor A (VEGFA) is among the most-significant stimulators of angiogenesis. Its effect on cardiovascular diseases and on the variation of related risk factors such as lipid parameters is considered important, although as yet unclear. Recently, we identified four common variants (rs6921438, rs4416670, rs6993770, and rs10738760) that explain up to 50% of the heritability of plasma VEGFA levels. In the present study, we aimed at assessing the contribution of these variants to the variation of blood lipid levels (including apoE, triglycerides, total cholesterol, low- and high-density lipoprotein cholesterol levels (LDL-C and HDL-C)] in he...
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Patient-Oriented and Epidemiological Research
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