publication . Article . Other literature type . 2008

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

Bordeleau, Marie-Eve; Robert, Francis; Gerard, Baudouin; Lindqvist, Lisa; Chen, Samuel M.H.; Wendel, Hans-Guido; Brem, Brigitte; Greger, Harald; Lowe, Scott W.; Porco, John A.; ...
Open Access
  • Published: 01 Jun 2008 Journal: Journal of Clinical Investigation (issn: 0021-9738, Copyright policy)
  • Publisher: American Society for Clinical Investigation
Abstract
Disablement of cell death programs in cancer cells contributes to drug resistance and in some cases has been associated with altered translational control. As eukaryotic translation initiation factor 4E (eIF4E) cooperates with c-Myc during lymphomagenesis, induces drug resistance, and is a genetic modifier of the rapamycin response, we have investigated the effect of dysregulation of the ribosome recruitment phase of translation initiation on tumor progression and chemosensitivity. eIF4E is a subunit of eIF4F, a complex that stimulates ribosome recruitment during translation initiation by delivering the DEAD-box RNA helicase eIF4A to the 5′ end of mRNAs. eIF4A i...
Subjects
free text keywords: General Medicine, Polysome, EIF4E, Messenger RNA, Eukaryotic translation, Eukaryotic Initiation Factor-4E, eIF4A, Biology, Eukaryotic Small Ribosomal Subunit, Initiation factor, Biochemistry, Research Article
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publication . Article . Other literature type . 2008

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

Bordeleau, Marie-Eve; Robert, Francis; Gerard, Baudouin; Lindqvist, Lisa; Chen, Samuel M.H.; Wendel, Hans-Guido; Brem, Brigitte; Greger, Harald; Lowe, Scott W.; Porco, John A.; ...