publication . Other literature type . Article . 2017

HGG-20. NEURONAL ACTIVITY PROMOTES PEDIATRIC GLIOMA INVASION

Tessa Johung; Kathryn Taylor; Humsa Venkatesh; Anna Geraghty; Michelle Monje;
Open Access English
  • Published: 31 May 2017
  • Publisher: Oxford University Press
Abstract
The diffusely infiltrating nature of pediatric high-grade glioma (pHGG) is a characteristic hallmark of this disease and represents a major contributor to the dire prognosis seen for pHGG of all neuroanatomical locations, most notably in H3K27M-mutant diffuse midline gliomas such as DIPG. Despite the fact that widespread infiltration is a defining aspect of this group of diseases, the molecular and cellular determinants of pHGG migration and invasion are not well understood. We have previously shown that neuronal activity regulates pHGG growth. Here, we investigated the role of neuronal activity on glioma invasion using conditioned media (CM) generated from opto...
Subjects
free text keywords: Abstracts, Glioma, medicine.disease, medicine, business.industry, business, Pathology, medicine.medical_specialty, Premovement neuronal activity
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publication . Other literature type . Article . 2017

HGG-20. NEURONAL ACTIVITY PROMOTES PEDIATRIC GLIOMA INVASION

Tessa Johung; Kathryn Taylor; Humsa Venkatesh; Anna Geraghty; Michelle Monje;