Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice

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Dewachter, Ilse; Reversé, Delphine; Caluwaerts, Nathalie; Ris, Laurence; Kuipéri, Cuno; Van den Haute, Chris; Spittaels, Kurt; Umans, Lieve; Serneels, Lutgarde; Thiry, Els; Moechars, Dieder; Mercken, Mark; Godaux, Emile; Van Leuven, Fred;

In the brain of Alzheimer's disease (AD) patients, neurotoxic amyloid peptides accumulate and are deposited as senile plaques. A major therapeutic strategy aims to decrease production of amyloid peptides by inhibition of γ-secretase. Presenilins are polytopic transmembr... View more
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