Pharmacodynamic effects of daclizumab in the intrathecal compartment

Article English OPEN
Komori, Mika; Kosa, Peter; Stein, Jason; Zhao, Vivian; Blake, Andrew; Cherup, Jamie; Sheridan, James; Wu, Tianxia; Bielekova, Bibiana; (2017)
  • Publisher: John Wiley and Sons Inc.
  • Journal: Annals of Clinical and Translational Neurology,volume 4,issue 7,pages478-490 (eissn: 2328-9503)
  • Related identifiers: doi: 10.1002/acn3.427, pmc: PMC5497534
  • Subject: Research Article | Research Articles
    mesheuropmc: eye diseases

Abstract Objective It was previously demonstrated that daclizumab therapy normalizes cellular cerebrospinal fluid (CSF) abnormalities typical of multiple sclerosis (MS) in the majority of treated patients. However, CSF cells represent only the mobile portion of intrathe... View more
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