A New Crucial Protein Interaction Element That Targets the Adenovirus E4-ORF1 Oncoprotein to Membrane Vesicles▿

Other literature type English OPEN
Chung, Sang-Hyuk; Frese, Kristopher K.; Weiss, Robert S.; Prasad, B. V. Venkataram; Javier, Ronald T.; (2007)
  • Publisher: American Society for Microbiology
  • Related identifiers: pmc: PMC1900153, doi: 10.1128/JVI.02855-06
  • Subject: Transformation and Oncogenesis
    mesheuropmc: biochemical phenomena, metabolism, and nutrition | viruses | bacteria

Human adenovirus type 9 exclusively elicits mammary tumors in experimental animals, and the primary oncogenic determinant of this virus is the E4-ORF1 oncogene, as opposed to the well-known E1A and E1B oncogenes. The tumorigenic potential of E4-ORF1, as well as its abil... View more
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