publication . Article . Other literature type . 2007

A New Crucial Protein Interaction Element That Targets the Adenovirus E4-ORF1 Oncoprotein to Membrane Vesicles

Sang-Hyuk Chung; Kristopher K Frese; Robert S Weiss; B V Venkataram Prasad; Ronald T Javier;
Open Access
  • Published: 21 Feb 2007 Journal: Journal of Virology, volume 81, pages 4,787-4,797 (issn: 0022-538X, eissn: 1098-5514, Copyright policy)
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p>Human adenovirus type 9 exclusively elicits mammary tumors in experimental animals, and the primary oncogenic determinant of this virus is the <jats:italic>E4-ORF1</jats:italic> oncogene, as opposed to the well-known <jats:italic>E1A</jats:italic> and <jats:italic>E1B</jats:italic> oncogenes. The tumorigenic potential of E4-ORF1, as well as its ability to oncogenically stimulate phosphatidylinositol 3-kinase (PI3K), depends on a carboxyl-terminal PDZ domain-binding motif (PBM) that mediates interactions with several different membrane-associated cellular PDZ proteins, including MUPP1, PATJ, MAGI-1, ZO-2, and Dlg1. Nevert...
Subjects
Medical Subject Headings: virusesbiochemical phenomena, metabolism, and nutrition
free text keywords: Immunology, Insect Science, Microbiology, Virology, Peptide sequence, Molecular biology, Biology, Transport protein, PDZ domain, Protein subunit, Immunoprecipitation, DLG1, biology.protein, Phosphoprotein, Plasma protein binding, Transformation and Oncogenesis
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p>Human adenovirus type 9 exclusively elicits mammary tumors in experimental animals, and the primary oncogenic determinant of this virus is the <jats:italic>E4-ORF1</jats:italic> oncogene, as opposed to the well-known <jats:italic>E1A</jats:italic> and <jats:italic>E1B</jats:italic> oncogenes. The tumorigenic potential of E4-ORF1, as well as its ability to oncogenically stimulate phosphatidylinositol 3-kinase (PI3K), depends on a carboxyl-terminal PDZ domain-binding motif (PBM) that mediates interactions with several different membrane-associated cellular PDZ proteins, including MUPP1, PATJ, MAGI-1, ZO-2, and Dlg1. Nevert...
Subjects
Medical Subject Headings: virusesbiochemical phenomena, metabolism, and nutrition
free text keywords: Immunology, Insect Science, Microbiology, Virology, Peptide sequence, Molecular biology, Biology, Transport protein, PDZ domain, Protein subunit, Immunoprecipitation, DLG1, biology.protein, Phosphoprotein, Plasma protein binding, Transformation and Oncogenesis
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publication . Article . Other literature type . 2007

A New Crucial Protein Interaction Element That Targets the Adenovirus E4-ORF1 Oncoprotein to Membrane Vesicles

Sang-Hyuk Chung; Kristopher K Frese; Robert S Weiss; B V Venkataram Prasad; Ronald T Javier;