publication . Article . Other literature type . 2007

association of stat4 with rheumatoid arthritis in the korean population

Lee, Hye-Soon; Remmers, Elaine F; Le, Julie M; Kastner, Daniel L; Bae, Sang-Cheol; Gregersen, Peter K;
Open Access
  • Published: 01 Jan 2007 Journal: Molecular Medicine, volume 13, pages 455-460 (issn: 1076-1551, eissn: 1528-3658, Copyright policy)
  • Publisher: Springer Nature
Abstract
A recent study in the North American White population has documented the association of a common STAT4 haplotype (tagged by rs7574865) with risk for rheumatoid arthritis (RA) and systemic lupus erythematosus. To replicate this finding in the Korean population, we performed a case-control association study. We genotyped 67 single nucleotide polymorphisms (SNPs) within the STAT1 and STAT4 regions in 1123 Korean patients with RA and 1008 ethnicity-matched controls. The most significant four risk SNPs (rs11889341, rs7574865, rs8179673, and rs10181656 located within the third intron of STAT4) among 67 SNPs are identical with those in the North American study. All fou...
Subjects
free text keywords: Genetics(clinical), Molecular Medicine, Genetics, Molecular Biology, Linkage disequilibrium, PTPN22, Risk factor, Single-nucleotide polymorphism, Allele frequency, Haplotype, Population, education.field_of_study, education, Odds ratio, Biology, Articles
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publication . Article . Other literature type . 2007

association of stat4 with rheumatoid arthritis in the korean population

Lee, Hye-Soon; Remmers, Elaine F; Le, Julie M; Kastner, Daniel L; Bae, Sang-Cheol; Gregersen, Peter K;