publication . Other literature type . Article . 2018

Neuropeptide Y-deficient mice show altered circadian response to simulated natural photoperiod

Hyun Jung Kim; Mary E. Harrington;
Open Access English
  • Published: 13 Nov 2018
Abstract
Abstract Circadian rhythms, endogenously generated by the suprachiasmatic nucleus (SCN), can be synchronized to a variety of photic and non-photic environmental stimuli. Neuropeptide Y (NPY) is produced in the intergeniculate leaflet (IGL) and known to mediate both photic and non-photic influences on the SCN. We recently found that npy−/− mice were slower to shift their locomotor activity onset to the new time of light offset when photoperiod was abruptly changed from light/dark (LD) cycle 18:6 to LD 6:18. In the present study, we measured the locomotor response of npy−/− mice to gradual changes in photoperiod (4 min a day) for 141 days (LD 16:8 changing to LD 8...
Subjects
Medical Subject Headings: sense organshumanitiesendocrine systemmental disorders
free text keywords: Article, Developmental Biology, General Neuroscience, Molecular Biology, Clinical Neurology, Neuropeptide Y receptor, Circadian response, Entrainment (chronobiology), Endocrinology, medicine.medical_specialty, medicine, Stimulus (physiology), Suprachiasmatic nucleus, Analysis of variance, Biology, Circadian rhythm, Internal medicine, photoperiodism
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