publication . Article . Other literature type . 2014

Phage display discovery of novel molecular targets in glioblastoma-initiating cells.

Liu, J K; Lubelski, D; Schonberg, D L; Wu, Q; Hale, J S; Flavahan, W A; Mulkearns-Hubert, E E; Man, J; Hjelmeland, A B; Yu, J; ...
Open Access
  • Published: 16 May 2014 Journal: Cell Death & Differentiation, volume 21, pages 1,325-1,339 (issn: 1350-9047, eissn: 1476-5403, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Glioblastoma is the most common primary intrinsic brain tumor and remains incurable despite maximal therapy. Glioblastomas display cellular hierarchies with self-renewing glioma-initiating cells (GICs) at the apex. To discover new GIC targets, we used in vivo delivery of phage display technology to screen for molecules selectively binding GICs that may be amenable for targeting. Phage display leverages large, diverse peptide libraries to identify interactions with molecules in their native conformation. We delivered a bacteriophage peptide library intravenously to a glioblastoma xenograft in vivo then derived GICs. Phage peptides bound to GICs were analyzed for ...
Subjects
free text keywords: Cell Biology, Molecular Biology, Bacteriophage, biology.organism_classification, biology, Peptide library, Phage display, Cellular differentiation, Carcinogenesis, medicine.disease_cause, medicine, RAC1, Peptide sequence, Epidermal growth factor receptor, biology.protein, Original Paper
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 2014

Phage display discovery of novel molecular targets in glioblastoma-initiating cells.

Liu, J K; Lubelski, D; Schonberg, D L; Wu, Q; Hale, J S; Flavahan, W A; Mulkearns-Hubert, E E; Man, J; Hjelmeland, A B; Yu, J; ...