Efforts to develop orally administered drugs tend to place an exceptional focus on aqueous solubility as this is an essential criterion for their absorption in the gastrointestinal tract. In this work we examine the solid state behavior and solubility of OZ439, a promis... View more
Moehrle J. J.; Duparc S.; Siethoff C.; van Giersbergen P. L. M.; Craft J. C.; Arbe-Barnes S.; Charman S. A.; Gutierrez M.; Wittlin S.; Vennerstrom J. L.First-in-man
safety and pharmacokinetics
of synthetic ozonide OZ439 demonstrates an improved exposure profile
relative to other peroxide antimalarials. Br.
J. Clin. Pharmacol.2013, 75 2 535–548 10.1111/j.1365-2125.2012.04368.x.