publication . Article . 1932

A STUDY OF THE DISSOCIATION OF THE RAWLINS STRAIN OF BACTERIUM TYPHOSUM WITH SPECIAL REFERENCE TO ITS USE IN THE PRODUCTION OF ANTI-TYPHOID VACCINE.

F B Grinnell;
Open Access English
  • Published: 01 Dec 1932 Journal: The Journal of Experimental Medicine, volume 56, issue 6, pages 907-918 (issn: 0022-1007, eissn: 1540-9538, Copyright policy)
  • Publisher: The Rockefeller University Press
Abstract
<jats:p>A study of the subcultures of the Rawlins strain of Bacterium typhosum used by twelve different laboratories for vaccine production showed that they all differed from recently isolated smooth strains in cultural characteristics, virulence and protective efficiency.</jats:p> <jats:p>Eleven of these Rawlins cultures gave both the flagellar and the somatic type of agglutination in anti-smooth rabbit serum, and the one culture so tested produced both flagellar and somatic agglutinins when injected into rabbits and man.</jats:p> <jats:p>Agglutination of neither the flagellar nor the somatic type can, therefore, be used as a test of the smoothness of a culture...
Subjects
free text keywords: Article, Immunology, Immunology and Allergy, Bacteria, biology.organism_classification, biology, Strain (chemistry), Immunity, Microbiology, Virulence, Agglutination (biology), Somatic cell, Typhoid vaccine, Vaccination
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