Synthesis of ent-Ketorfanol via a C–H Alkenylation/Highly Torquoselective 6π-Electrocyclization Cascade

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Phillips, Eric M.; Mesganaw, Tehetena; Patel, Ashay; Duttwyler, Simon; Mercado, Brandon Q.; Houk, Kendall N.; Ellman, Jonathan A.;

The asymmetric synthesis of ent-ketorfanol from simple and commercially available precursors is reported. A Rh(I)-catalyzed intramolecular C–H alkenylation/highly torquoselective 6π-electrocyclization cascade provides a fused bicyclic 1,2-dihydropyridine as a key interm... View more
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