publication . Other literature type . 2011

TOMM40 poly-T variants and Cerebrospinal Fluid Amyloid Beta levels in the elderly

Pomara, Nunzio; Bruno, Davide; Nierenberg, Jay J.; Sidtis, John J.; Martiniuk, Frank T.; Mehta, Pankaj D.; Zetterberg, Henrik; Blennow, Kaj;
Open Access English
  • Published: 01 Apr 2011
Abstract
A variable poly-T polymorphism in the TOMM40 gene, which is in linkage disequilibrium with APOE, was recently implicated with increased risk and earlier onset age for late-onset Alzheimer’s disease in APOE ε3 carriers. To elucidate potential neurobiological mechanisms underlying this association, we compared the effect of TOMM40 poly-T variants to the effect of APOE, an established LOAD-risk modulator, on cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau levels, in cognitively intact elderly subjects. APOE ε4 carriers showed significant reductions in Aβ 1-42 levels compared to non-ε4 carriers, but no differences were detected across TOMM40 variants. Neither Aβ...
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Other literature type . 2011
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